The small GTP ase Arf1 modulates mitochondrial morphology and function
نویسندگان
چکیده
منابع مشابه
The small GTPase Arf1 modulates mitochondrial morphology and function.
The small GTPase Arf1 plays critical roles in membrane traffic by initiating the recruitment of coat proteins and by modulating the activity of lipid-modifying enzymes. Here, we report an unexpected but evolutionarily conserved role for Arf1 and the ArfGEF GBF1 at mitochondria. Loss of function of ARF-1 or GBF-1 impaired mitochondrial morphology and activity in Caenorhabditis elegans. Similarly...
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ARL4D, ARL4A, and ARL4C are closely related members of the ADP-ribosylation factor/ARF-like protein (ARF/ARL) family of GTPases. All three ARL4 proteins contain nuclear localization signals (NLSs) at their C-termini and are primarily found at the plasma membrane, but they are also present in the nucleus and cytoplasm. ARF function and localization depends on their controlled binding and hydroly...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2014
ISSN: 0261-4189,1460-2075
DOI: 10.15252/embj.201489039